:For the high school in Tempe, Arizona, see Marcos de Niza High School.
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He was born in Nice (de Niza means of Nice in Spanish)), which was at that time under the control of the Italian House of Savoy.
Friar Marcos de Niza, a member of the sect, had led Coronado's expedition to find Cíbola only to find the villages of the Zuni.
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He succeeded Fray Marcos de Niza, a Franciscan friar, as the Provincial of the province of the Holy Gospel, making de Soto the fourth provincial of the province of the Holy Gospel.