East of MD 543, MD 22 reduces to two lanes and passes through farmland with scattered residential subdivisions where the highway passes the historic homes Dibb House and Tudor Hall, the latter notable for being the boyhood home of John Wilkes Booth.
Maryland | University of Maryland | Bethesda, Maryland | Annapolis, Maryland | Silver Spring, Maryland | Montgomery County, Maryland | U.S. Route 66 | U.S. Route 1 | Cumberland, Maryland | Governor of Maryland | Frederick, Maryland | Maryland House of Delegates | Hagerstown, Maryland | U.S. Route 6 | U.S. Route 101 | Route 66 | Emmitsburg, Maryland | Columbia, Maryland | Westminster, Maryland | U.S. Route 30 | New Jersey Route 4 | European route E65 | U.S. Route 40 | Laurel, Maryland | Howard County, Maryland | Havre de Grace, Maryland | California State Route 1 | University of Maryland, Baltimore | Bowie, Maryland | U.S. Route 1 in Maine |
The stadium is part of Cal Ripken, Jr.'s Aberdeen Complex in his hometown of Aberdeen, Maryland, located just off Interstate 95 at Maryland Route 22.