Filomarino is of particular interest in the history of Naples since he was cardinal during two especially turbulent periods: Masaniello's revolt in 1645 and the severe plague epidemic of 1656.
One of his best known paintings is a depiction of the Revolt of Masaniello in the Piazza del Mercato in Naples, with figures by Cerquozzi, painted for Cardinal Bernardino Spada in 1648 and now in the Galleria Spada in Rome.
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After relocating to Rome following the revolt of Masaniello in 1647, he collaborated with painters from the circle of Dutch painters active in Rome, known as Bamboccianti, especially Michelangelo Cerquozzi and Jan Miel.