Other villains may include the Bug's archenemy Halloween (based on the Green Goblin), although the appearance of Halloween throwing Kristen off the Golden Gate Bridge (modeled after the death of Spider-Man's former girlfriend Gwen Stacy) turned out to be a ploy to distract Superman.
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Hornet has commented that the team seems to spend most of the time fighting itself, most notably a battle with former member the Chaos Witch in which Bowman was killed (a reference to the Scarlet Witch and the events of Avengers Disassembled).