Zeffane then made his debut for the senior Lyon team on 6 December 2012 in the Europa League against Israeli Premier League side Ironi Kiryat Shmona at the Stade de Gerland in which he played the whole 90 minutes and assisted on Lyon's second goal of the night from Yassine Benzia in the 58th minute as Lyon ran out 2–0 winners.
Mehdi Belhaj Kacem | Mehdi Ghezali | Mehdi Karroubi | Mehdi Hashemi | Mohammad Mehdi Behkish | Mehdi Tartar | Mehdi Norowzian | Mehdi Meriah | Mehdi Mahdavikia's | Mehdi Kazemi | Mehdi Jafari | Mehdi Huseynzade | Mehdi Hasan | Mehdi Golshani | Mehdi El Glaoui | Mehdi Ben Barka | Mehdi Amirabadi | Amir Mehdi |