He noted the “curious fact… that the interval of a single night will greatly increase the strength of the memory,” and presented the possibility that “… the power of recollection .. undergoes a process of ripening and maturing during the time which intervenes.” The process of consolidation was later proposed based on clinical data illustrated in 1882 by Ribot’s Law of Regression, “progressive destruction advances progressively from the unstable to the stable”.
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This activation then triggers the synthesis of important proteins related to LTP, ultimately leading to synapse growth and eventually long-term memory.
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