Tony Award–winning actor Norbert Leo Butz and Emmy Award–winning actor Michael Emerson were two of the program's most successful alumni.
Michael Jackson | Order of St Michael and St George | Ralph Waldo Emerson | Michael Bloomberg | Michael Jordan | Michael Caine | Michael | Michael Palin | Michael Moore | George Michael | Michael Dukakis | Michael W. Smith | Michael Douglas | Michael Bolton | Emerson, Lake & Palmer | Michael Schumacher | Michael J. Fox | Michael Bublé | Emerson | Michael Faraday | Michael Moorcock | Michael Kors | Michael Brecker | Michael Bay | Michael Nyman | Keith Emerson | Michael Phelps | Michael Ondaatje | John Michael Montgomery | St. Michael |
The actors for Ben Linus (Michael Emerson), Sun (Yunjin Kim), Desmond (Henry Ian Cusick), Claire (Emilie de Ravin), Tom (M. C. Gainey) and Mikhail Bakunin (Andrew Divoff) all provided voice work for the game, while the rest of the major characters are provided by stand-ins.