The show featured many special guest stars which include Mike Epps, Cheryl Tiegs, Miley Cyrus, LL Cool J, Rihanna, Michael Rapaport, and Robbi Morgan.
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The plot follows two married friends, Marty (Michael Rapaport) and Paul (Bryan Callen), who hire their single playboy friend Mike (John Stamos) to "help them get their mojo back" in order to save their marriages.
The cast also includes: Thomas Sangster as Rob, a young disabled man and the target of the Oodie's rescue job; Zoë Bell as Rose, Serinda Swan as Jez, Meagan Good as Belle, Brea Grant as Pammy, and Agnes Bruckner as Mona, a group of female biker assassins; Michael Rapaport as Lucky, a bar owner; James DuMont as Special Agent Simmons; and Natalie Martinez as Ariana, an illegal immigrant and nurse.