In the 1960s, William S. Condon pioneered the study of interactions at the fraction-of-a-second level.
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Microexpressions and associated science are the central premise for the 2009 television series Lie to Me, in which the main character uses his acute awareness of microexpressions and other body language clues to determine when someone is lying or hiding something.
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They also play a central role in Robert Ludlum's posthumously published The Ambler Warning, in which the central character, Harrison Ambler, is an intelligence agent who is able to see them.