Laodice bore Mithridates a son, Antiochus I Theos of Commagene (c. 86 BC–38 BC), a prince and future king of Commagene.
King Mithridates I Callinicus of Commagene
Tryphaena also bore her husband a daughter called Laodice, who became the wife of Mithridates I Callinicus.
Mithridates VI of Pontus | Mithridates I of Parthia | Mithridates I Callinicus | Mithridates | Seleucus II Callinicus | Mithridates III of Commagene | Mithridates II of Commagene | Laodice (wife of Mithridates II of Pontus) | Laodice (wife of Mithridates III of Pontus) | Callinicus |
Laodice VII Thea, married to king Mithridates I Callinicus of Commagene as part of a settlement by Mithridates' father Sames II Theosebes Dikaios to ensure peace between the Kingdom of Commagene and the Seleucid Empire.