Before the arrival of the conquistadores in the 16th Century the area was populated by ethnic Sanavirónes and Mocovíes.
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Native Argentines on the other hand have significant populations in the country's North-West (Quechua, Diaguita, Kolla, Aymara); in the North-East (Guaraní, Mocoví, Toba, Wichí); and in the Patagonia or South (Mapuche, Tehuelche).