On August 1, 1979, the Cooperative Agreement between Tufts University and the USDA was signed, and on October 23 of the same year, the National Institute on Aging and the USDA signed a Memorandum of Understanding detailing their mutual interest in the HNRCA at Tufts University.
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In early 2006, a group of researchers led by adventure writer Dan Buettner and supported by National Geographic Magazine, the National Institute on Aging, and Allianz Healthcare, designated Nicoya as a Blue Zone.
The Interventions Testing Program (ITP) is funded by the Biology of Aging Program of the National Institute on Aging (NIA) to evaluate compounds for their effects on lifespan and age-related biomarkers.