She studied fine art at the University of Minnesota, Minneapolis, MN and then transferred to the San Francisco Art Institute, where she graduated with a Bachelors in Fine Arts in Sculpture and Video Performance in 1980.
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Her illustrations have been commissioned and licensed from companies such as, Innovative Kids, Nickelodeon, Penguin Putnam, Ravensburger, Rocky Mt. Elk Foundation, Scholastic, SunsOut and the U.S.D.A..
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Twinem developed a unique painting technique that bears inspiration from the native art and textiles of Oaxaca and other traditional Mexican folk art.