Using bacterial luciferase as a reporter for gene expression, studies have shown that, similar to Drosophila, mouse, and Neurospora clock models, the Synechococcus circadian clock is based on a negative feedback loop.
In 1955, he received his Ph.D. from California Institute of Technology in biochemistry with a specialization in immunology for studies on cytochrome in Neurospora.
Frq- The Frq gene, also known as the Frequency gene, encodes central components of an oscillatory loop within the circadian clock in Neurospora.