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As a son-in-law of Ivan Betskoy and a secretary to Prince Potemkin, he became one of the earliest administrators of the New Russia.
In 1824 he was appointed by Mikhail Semyonovich Vorontsov, governor-general of New Russia, to the Russian Imperial Botanical Garden at Nikita in Yalta on the south coast of the Crimea.
Although macroscopically Ukraine was fought over by several powers: Austro-Hungary, Germany, Poland, Romania; Ukrainian People's Republic, the Anarchist Black Army as well as the Red Army and the White Army, the population of New Russia by large allied themselves only with the latter three.
In addition to writing on the history of scientific theories, Graham has written much on the organization of science in Russia and the Soviet Union, including a book on the early history of the Soviet Academy of Sciences (The Soviet Academy of Sciences and the Communist Party) and a more recent one on the situation of science in Russia after the collapse of the Soviet Union (Science in the New Russia, written together with Irina Dezhina).