North Carolina | North America | South Carolina | North Rhine-Westphalia | North Korea | North Yorkshire | highway | University of North Carolina at Chapel Hill | North Island | North Sea | North Africa | North Dakota | North | Raleigh, North Carolina | Chapel Hill, North Carolina | University of North Carolina | Scarborough, North Yorkshire | North Pole | North Vietnam | Columbia, South Carolina | North Shore | London and North Western Railway | state highway | Carolina Panthers | North American Soccer League | Asheville, North Carolina | University of South Carolina | North Carolina State University | Greensboro, North Carolina | Princes Highway |
Established in 1933 as a new primary routing, NC 581 originally traversed from US 264/NC 91, in Bailey, north to US 64/NC 90, in Spring Hope.