They are found in nurse cells of the developing Drosophila melanogaster egg chamber and are composed of various types of proteins, including RNA-helicases, Tudor domain proteins, Piwi-clade Argonaute proteins, in addition to a PRMT5 methylosome composed of Capsuléen and its co-factor, Valois (MEP50).
The gene Maelstrom, Mael, creates a protein, which was first located in Drosophila melanogaster in the nuage perinuclear structure and has functionality analogous to the spindle, spn, gene class.
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