After the Revolutionary War, Shawnees of the Ohio Country began to forge a confederacy to oppose U.S. occupation of the land ceded by the British.
Trying to improve relations with the Native Americans to encourage trade and avoid conflicts with colonists, George III in his Royal Proclamation of 1763 placed the Ohio Country in what was declared an Indian Reserve, stretching from the Appalachian Mountains west to the Mississippi River and from as far north as Newfoundland to Florida.
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Colonists in the Thirteen Colonies considered this one of the Intolerable Acts passed by Parliament, without their consent, and contributing to the American Revolution.
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On June 22, 1774, the British Parliament passed the Quebec Act; it annexed the region to the province of Quebec.
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After the war, he moved his people into Ohio Country, where he made treaties with the Continental Congress to try to protect Lenape land, but settlers continued to encroach on his people.
During the American Revolution, the Munsee- and Unami-speaking Lenni Lenape (also called Delaware) bands of the Ohio Country were deeply divided over which side, if any, to take in the conflict.
Cape Girardeau County was first settled by mix of French Canadian and Shawnee refugees who had fled with Lorimier from Pickawillany in the Ohio Country.
The Pennsylvania Canal was conceived in the mid-1820s by Philadelphia merchants inspired by the obvious impact of the Lehigh Canal and the emerging markets of the three decades of steady emigration into the near west, the Ohio Country and Northwest Territory and other lands of the Louisiana Purchase (1803).
This encompasses the French settlements and territories that spread from Acadia in the East through the Saint Lawrence Valley, the Great Lakes region, the Ohio Valley, and south to Louisiana from the 16th to the 18th centuries.
After constructing Fort Juniata Crossing near present Breezewood, Pennsylvania, Colonel Bouquet began planning Fort Bedford as the next step towards the Ohio Country.
George Washington was sent by British to Fort Le Boeuf to deliver a message to the French that demanded that they leave the Ohio Country.
Governor Patrick Henry of Virginia wanted to retaliate by attacking Pluggy's Town in the Ohio Country, but he canceled the expedition for fear that the militia would be unable to distinguish between neutral and hostile Indians, and thus make enemies of the neutral Delawares and Shawnees.