The citizens protested, and gained the support of the Battelle Memorial Institute, located on Plain City-Georgesville Rd between US 40 and the proposed I-70.
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The western terminus of this state highway is at a signalized intersection that marks the confluence of U.S. Route 42, State Route 38, State Route 56 and State Route 142 in downtown London.
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When it was first designated in 1937, State Route 665 was routed along its present alignment between the junction of U.S. Route 42, State Route 38, State Route 56 and State Route 142 in London and U.S. Route 23 near Lockbourne.