The district formed with the merger the former districts of Ohrekreis and Bördekreis as part of the local-government reform of 2007.
1822: Heinrich Pröhle was born in Satuelle (then in Neuhaldensleben, Ohrekreis, German Confederation) as the son of the Lutheran pastor and hobby poet Heinrich Andreas Pröhle.
In this year the districts Haldensleben and Wolmirstedt were united to form the Ohrekreis, with the seat of district administration in Haldensleben.