Istrati dealt with the mounting persecution of Old Bolsheviks and the gradual victimization of whole population groups.
In September 1937 Stalin dispatched Anastas Mikoyan, along with Georgy Malenkov and Lavrentiy Beria, with a list of 300 names to Yerevan to oversee the liquidation of the Communist Party of Armenia (CPA), which was largely made up of Old Bolsheviks.