"One Giant Leap", the third episode of the NBC supernatural drama series Heroes
In the episode "One Giant Leap", Simone takes down a painting of Claire and Zach and tells Isaac that she is selling the paintings so that he can go to rehab.
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"That's one small step for (a) man, one giant leap for mankind", the famous words of Apollo 11 Commander Neil Armstrong when he became the first human to both set foot on the Moon, and the first human to step onto another world.
According to the game rules "It's one false step for Mankind, one giant leap for you." This is a clear play on astronaut Neil Armstrong's first spoken words on the surface of the moon in 1969.