Born near Hurumu in modern Ethiopia, Onesimos lost his father when he was four years old.
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He was sent to Johannelunds Teologiska Högskola in Bromma, Sweden for five years to receive further education; upon his return to Massawa, he married Mehret Hailu.
In 1904 Onesimos Nesib arrived at Nejo to establish a mission, together with his wife, his children, and a group of associates including Aster Ganno.
It is a burial place of Onesimos Nesib, a famous Oromo who translated the Bible to Oromo Language for the first time, in collaboration with Aster Ganno.
The few works that had been published, most notably Onesimos Nesib's and Aster Ganno's translation of the Bible from the late nineteenth century, were written in the Ge'ez alphabet, as was the 1875 New Testament produced by Krapf.