It starts Osmaniye neighborhood in Bakırköy district on the European part, runs through the city over the Golden Horn and the Bosporus, and terminates in Söğütlüçeşme neighborhood of Kadıköy district on the Asian part.
The O-52 starts from the eastern terminus of Adana Beltway O-50, runs eastward through Osmaniye, Gaziantep and terminates north of Şanlıurfa.
Yarbaşı, Düziçi, a town in the district of Düziçi, Osmaniye Province