He made his first assemblage works in 1968 and appeared in his first "Happening" that same year in Quito.
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He began to exhibit his work internationally in the 1960s including the 1964 Bienale of Córdoba, Argentina, and the 1969 São Paulo Bienal for which he received honorable mention.
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He began his education as a student of architecture at the Central University of Quito in 1951.
Oswaldo Guayasamín | Rubén Oswaldo Díaz | Oswaldo Viteri | Oswaldo Goeldi | Oswaldo Cruz | Cynthia Viteri |
Rendón preached, "the task of the painter is to organize the possibilities that are offered to him." The work of Manuel Rendón is vast and has greatly influenced generations of master artists throughout Latin America and Europe, such as Antoni Tàpies, Antonio Saura, Enrique Tábara, Estuardo Maldonado, Carlos Catasse, Félix Arauz, Aníbal Villacís, Oswaldo Viteri and Theo Constanté, to name a few.