The motorway starts from the west terminus of Adana Beltway O-50, runs westward reaching the south terminus of Pozantı-Adana Motorway O-21 northeast of Tarsus, continues southwest to Mersin bypassing it at north and terminates in Erdemli.
The O-52 starts from the eastern terminus of Adana Beltway O-50, runs eastward through Osmaniye, Gaziantep and terminates north of Şanlıurfa.