The music video for "Crosseyed and Painless" was produced by Toni Basil.
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The "rhythmical rant" in "Crosseyed and Painless"—"Facts are simple and facts are straight. Facts are lazy and facts are late."—is influenced by old school rap, specifically Kurtis Blow's "The Breaks" given to Byrne by Frantz.
In 1929 Mallory and Soma Weiss, a physician at Harvard, described 15 cases of severe, painless hemorrhage caused by a tear in the mucosa of the esophagus or gastroesophageal junction preceded by vomiting in alcoholic patients.
Recently, Henderson has appeared in a commercial for the 2008 Cadillac CTS, and the House episode "Painless".
The tracks "Looking For You" and "Parting Would be Painless" were both covered by Roger Daltrey and released on his solo album Parting Should Be Painless (released in 1984).