In 1975 Czech physicians described the result of a clinical trial in joint pain in The Lancet.
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It was the group of the Nobel prize laureate Rita Levi-Montalcini who in 1993 first presented evidence supporting that lipid amides of the N-acylethanolamine type (such as PEA) are potential prototypes of naturally occurring molecules capable of modulating mast cell activation, and her group coined the acronym ALIA in that paper.