The Cathedral of the Holy Spirit, alternatively known as the St. Esprit Cathedral (Italian: Cattedrale di Santo Spirito or Cattedrale dello Spirito Santo), located on Cumhuriyet Avenue, 205/B, in the quarter of Pangaltı in Şişli district, the former Harbiye, between Taksim Square and Nişantaşı, is one of the principal Catholic churches in Istanbul, Turkey.