The Cathedral of the Holy Spirit, alternatively known as the St. Esprit Cathedral (Italian: Cattedrale di Santo Spirito or Cattedrale dello Spirito Santo), located on Cumhuriyet Avenue, 205/B, in the quarter of Pangaltı in Şişli district, the former Harbiye, between Taksim Square and Nişantaşı, is one of the principal Catholic churches in Istanbul, Turkey.
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Along with the Cathedral of the Holy Spirit (1846) in the Harbiye district, St. Louis of the French (1581) and Santa Maria Draperis in Beyoğlu, Sts. Peter and Paul (1841) in Galata, Assumption Church in the Moda quarter of Kadıköy, St. Stephen in Yeşilköy and Bakırköy Church in Bakırköy, St. Anthony of Padua is one of the most important Catholic churches in Istanbul, and among them has the largest community following its Masses.
There are many churches and synagogues throughout the country, such as the Church of St. George, the St. Anthony of Padua Church, the Cathedral of the Holy Spirit, the Neve Shalom Synagogue, the Italian Synagogue and the Ashkenazi Synagogue in Istanbul.