It passes many other major roads in Sydney such as the Hume Highway, Woodville Road, Centenary Drive and Old Canterbury Road.
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Imprisoned at Longbottom Stockade (which was located at what is now Concord Oval), the convicts broke stone for the construction of Parramatta Road and collected oyster shells for making lime.
The City West Link then became part of Metroad 4 (now A4), relieving a congested section of Parramatta Road.
Greg Morelli was killed in a motorcycle accident in the early morning hours of 20 November 2008 after hitting a greasy patch of the road during a severe storm on Parramatta Road in North Strathfield.