Jim Pastorius (James W. Pastorius) (1881–1941), professional baseball player
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Francis Daniel Pastorius (1651 – c. 1720), leader of the first organized settlement of Germans in Pennsylvania
Despite the Quaker sympathies of Pastorius, his name was appropriated in 1942 by the Abwehr of Nazi Germany for "Operation Pastorius," a failed sabotage attack on the United States in World War II that included a target in Philadelphia.