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On his return in December, Tyrie was sent to the University of Pont-à-Mousson, as professor of Scripture and head of the Scots College, and two years later, on the successive deaths of Fathers Edmund Hay and Paul Hoffaeus, he was again called to Rome (22 May, 1592), where he became Assistant for France and Germany, and played his part in the Sixth General Congregation of the Society of Jesus (1593).
From Munich, where he was succeeded in 1565 by the celebrated Paul Hoffaeus, he was transferred to Dillingen, where for twenty years he presided over the college and the academy and laboured with zeal and success for the improvement of studies and for the religious training of the students.