Following this intersection, the route heads through more farmland prior to reaching the southern terminus of PA 143.
The route runs from U.S. Route 222 (US 222) in Kutztown north to PA 143 in Albany Township.
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After passing Albany Township Elementary School, the designation terminates at an intersection with PA 143 south of Trexler.
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Greenwich is crossed east-to-west by Interstate 78, which has interchanges with north-to-south Routes 143 and 737 in the township.