U.S. Route 209 climbs up inside the V-shaped gully of the westernmost of these from the beginning terminus junction with PA-54 within downtown Nesquehoning up over the ridge to the headwaters region of the Panther Creek Valley across the Nesquehoning Ridge drainage divide into the valley formed with Pisgah Ridge.
It is located in Mt. Carmel Township at the junction of Routes 54 and 61.
The creek and its tributaries can be accessed via a number of township roads and also via Pennsylvania Route 44 and Pennsylvania Route 54.
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