X-Nico

unusual facts about Phosphodiesterase


2',3'-Cyclic-nucleotide 3'-phosphodiesterase

Deletion of the C-terminus of CNP or phosphorylation abolish the catalytic activity of microtubule formation.


Cilomilast

Phosphodiesterase (PDE) inhibitors, such as theophylline, have been used to treat Chronic Obstructive Pulmonary Disease (COPD) for centuries; however, the clinical benefits of these agents have never been shown to out-weigh the risks of their numerous adverse effects.

Ectonucleotide pyrophosphatase/phosphodiesterase 1

Ectonucleotide pyrophosphatase/phosphodiesterase 1 has been shown to interact with Insulin receptor.

Equatorial spitting cobra

The venom of the Equatorial spitting cobra exhibited the common characteristic enzymatic activities of Asiatic spitting cobra venoms: low protease, phosphodiesterase, alkaline phosphomonoesterase and L-amino-acid oxidase activities, moderately high acetylcholinesterase and hyaluronidase activities and high LIG1

Aprataxin (a phosphodiesterase) has been shown to act on aborted DNA intermediates via hydrolysis of the AMP-phosphate bond, restoring the DNA to its initial state before the ligase had reacted.


see also