Isabella's marriage proved difficult, largely due to Edward's intimate relationship with his close friend and probable lover, Piers Gaveston.
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On 9 June 1312 the Earl of Pembroke was escorting Piers Gaveston south after Gaveston's surrender to a group of rebellious earls at Scarborough Castle.
The late earl's sisters, Eleanor, Margaret (now widowed after the death of Piers Gaveston) and Elizabeth were by 1317 all married to favourites of Edward II: Hugh Despenser the Younger, Hugh de Audley and Roger d'Amory respectively.
Later Edward II bestowed it briefly to his favourite Piers de Gaveston and then under Edward II it passed in 1345 to John de Warenne, Earl of Surrey.
La Cerda's fate paralleled that of Edward II of England's Piers Gaveston and John II of Castile's Alvaro de Luna; the position of a royal favourite was a dangerous one.
Bereford was associated with Piers Gaveston, a favorite of Edward II, perhaps because he had bought land in the Honour of Wallingford held by the earl.