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4 unusual facts about Prenylation


Prenylation

Farnesyltransferase and Geranylgeranyltransferase I are very similar proteins.

Instead, Rab proteins are bound by the Rab escort protein (REP) over a more conserved region of the Rab protein and then presented to the Rab geranylgeranyltransferase.

Small molecules can also undergo prenylation, such as in the case of prenylflavonoids.

In the case of the K- and N-Ras forms of Ras, when cells are treated with FTIs, these forms of Ras can undergo alternate prenylation in the form of geranylgeranylation.


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