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In 1995, the President of Uzbekistan, Islam Karimov, gave him the position of chief of the SNB as a counter weight to his rival's power, Zokir Almatov, the Minister of Internal Affairs.
The encyclopedia praises Islam Karimov, the current president of Uzbekistan, and his administration.
In 2003, while he was the foreign minister, allegations surfaced about his possible marriage to Gulnara Karimova, the daughter of the President of Uzbekistan Islam Karimov, and President Karimov's alleged plans for his replacement by Safoyev.