NLRP8 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.
Interaction with other proteins (e.g. the adaptor molecule ASC) is mediated via N-terminal pyrin (PYD) domain.
Composers with works in the Old Hall Manuscript include Leonel Power, Pycard, William Typp, Thomas Byttering, Oliver, Chirbury, Excetre, John Cooke, Roy Henry (probably King Henry V, but possibly King Henry IV), Queldryk, John Tyes, Aleyn, Fonteyns, Gervays, Lambe, Nicholas Sturgeon, Thomas Damett, and others.