San Carlos de Río Negro was visited from May 7 to May 10, 1800 for the expedition of Alexander von Humboldt and Aimé Bonpland, constituting the most southern point of their (périplo) for the Amazon Basin.
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José Solano set up his exploration base in that place, in the margins of the Rio Negro, and there he settled with the few men that had survived the ascent along the Orinoco River, since most, including the famous Swedish botanist Pehr Löfling that accompanied the expedition, they had succumbed prey of the tropical diseases, especially the yellow fever.
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