For example, the Ran GEF, RCC1, is present in the nucleus while the Ran GAP is present in the cytosol, modulating nuclear import and export of proteins.
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RCC1 is the guanine nucletoot change factor for Ran GTPase.
It has the opposite function of the RCC1, a nuclear-located protein that converts RanGDP to RanGTP.
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Together with RCC1 and components of the nuclear pore, RanGAP has been suggested to have evolved at the origin of eukaryotes.
It shares sequence homology with mammalian proteins involved in regulating chromatin condensation, for example the human RCC1 gene product.
RCC1 |