From 1822 to 1842 he was charged by the New Granada government with founding scientific institutions.
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The centralist structure that came to be in the Republic of New Granada after the disestablishment of Gran Colombia and that was ratified by the constitution of 1843, was soon challenged; particularly the provinces of Azuero, Chiriquí, Panamá, and Veraguas, who were demanding an autonomous status.
In 1851, he was appointed Chargé d'Affaires to New Granada by President Millard Fillmore, and resigned in April 1853 due to poor health.