A quarter of a mile further on the Medlock enters the Irwell adjacent to the bottom gate of the disused Hulme Locks.
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It is visible under a bridge on Baring Street, close to Piccadilly Station, before running again in a culvert beneath the former UMIST campus (London Road (A6) to Princess Street), then under Hulme Street, until it appears briefly at Gloucester Street before flowing under the former gasworks at Gaythorn, reappearing at City Road East.
UMIST is on land which used to be home to a large number of dyers' factories by the River Medlock, which now runs through underground culverts beneath the site.
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