Specialists in 15th-century art attribute the painting to the school of the Brussels painter Rogier van der Weyden, or an anonymous disciple of the school.
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By the mid-15th century andachtsbilder were influencing large monumental works, a process James Snyder discusses in relation to major works such as Rogier van der Weyden's Prado Deposition, the Isenheim Altarpiece of Matthias Grünewald and the carved Altarpiece of the Holy Blood by Tilman Riemenschneider at Rothenburg ob der Tauber.
Leon Battista Alberti wrote his De Re Aedificatoria under Leonello's commission, and at the Ferrarese court worked artists such as Pisanello, Iacopo Bellini, Giovanni da Oriolo, Andrea Mantegna, Piero della Francesca and the Netherlandish Rogier van der Weyden.
She is deeply influenced by Early Renaissance Flemish painters like Jan van Eyck, Rogier van der Weyden and Robert Campin, particularly with their usage of colour and lighting in their works.