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Luca Antonio Pirozzo, better known as St. Humilis of Bisignano (1582–1637), was a Franciscan monk born in Bisignano.
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An alternative version maintains that it was Skanderbeg's niece Irene Castriota, Duchess of San Pietro di Galatina and wife of Pietro Antonio Sanseverino, Prince of Bisignano, who invited Albanians to settle in the area.
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According to Henry Yule, Giovanni de Marignolli, famous for his account of travels in China, was made bishop of Bisignano in 1354.
Bisignano is the ancient Besidias, or Besidianum, which in the eleventh century became the residence of a Norman count and later a fief of the Orsini.
Salvatore Nunnari, Apostolic Administrator (08/10/2010 – 12/05/2012) Metropolitan Archbishop of Cosenza–Bisignano
Gero was employed at some unknown time as maestro di cappella for Pietro Antonio Sanseverino, the Prince of Bisignano, according to the dedicatory epistle to Gero's 1555 book of motets.