In 1990 the hospital was having difficulty handling the growing number of HIV/AIDS patients, and realized there was a need for counselling patients and their families as well as providing clinical care.
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In 1894 the Apostolic Vicariate of Victoria–Nyanza was split into the vicariates of Southern Victoria Nyanza, south of Lake Victoria, an eastern portion called "Upper Nile" that was given to the English Mill Hill Missionaries, and a northern portion called "Northern Nyanza" that covered the south and west of today's Uganda.