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Following Seagulls Over Sorrento, he acted in many plays, including Agatha Christie's Rule of Three and The Devil's Disciple, where he met and formed a friendship with Tyrone Power.
It was established in 1925 by Karl Pearson as the Annals of Eugenics, with as subtitle, Darwin's epigram "I have no Faith in anything short of actual measurement and the rule of three".
He started to write novels late in life, but he obtained an overwhelming success with El manuscrito carmesí (The Crimson Manuscript, Planeta Prize 1990), Águila Bicéfala (Two-Headed Eagle, 1994), La regla de tres (The Rule of Three, 1996) and La pasión turca (Turkish Passion, 1993), adapted for the cinema by Spanish director Vicente Aranda and Más allá del Jardín (Beyond the Garden, 1995), adapted by Pedro Olea.
The Rule of Three gained notoriety for being particularly difficult to explain: see Cocker's Arithmetick for an example of how the premier textbook in the 17th century approached the subject.
The screenplay for "Rule of Three" was penned by Rhoda Jordan, and explores themes involving karma along with Shapiro's more familiar revelatory content.