Because the binding of the polymerase to the template is the rate-limiting step in DNA synthesis, the overall rate of DNA replication during S phase of the cell cycle is dependent on the processivity of the DNA polymerases performing the replication.
The pulse of G1/S cyclins causes CLN3-Cdk1 to activate Cln1/2, (Start point (yeast)) as well as Clb5/6 at the initiation of S-phase.
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BrdU can be incorporated into the newly synthesized DNA of replicating cells (during the S phase of the cell cycle), substituting for thymidine during DNA replication.
Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA).
It was part of Delhi Metro's Phase-3 plan and minor modification to the route may have to be done to adhere to the ASI construction norms in protected heritage areas.
After a period of hesitation, he was eventually convinced by the encouragement of both Shiina and bassist Seiji Kameda, who is said to have told him "Hurry up and join so we can play together", and Izawa debuted later the same year as a member of Tokyo Jihen's Phase 2 lineup alongside new guitarist Ryousuke Nagaoka, nicknamed Ukigumo.