Inactivating mutations in SMARCB1, formerly known as hSNF5/INI1 and a component of the human SWI/SNF remodeling complex have been found in large number of rhabdoid tumors, commonly affecting pediatric population.
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There are at least five families of chromatin remodelers in eukaryotes : SWI/SNF, ISWI, NuRD/Mi-2/CHD, INO80 and SWR1 with first two remodelers being very well studied so far, especially in the yeast model.
Among the most frequently mutated genes are components of the SWI/SNF chromatin remodeling complex, which are lost in about 20% of tumors.
The rate of transcription for SWI/SNF and HDAC complexes seem to be regulated by the INI1 gene.
SNF currently sponsors 12 brilliant children coming from back warded families of villages like Aarupokhari, Manbu of Gorkha.
The Società di Navigazione e Ferrovie per lago di Lugano (SNF) was formed in 1873 to construct and operate a transport link from Menaggio, on Lake Como, to Luino, on Lake Maggiore, via Lugano.